Pathologic 2 is an open world survival horror game set in a town being consumed by a deadly plague. As the only sane medic around, it's your job to save everyone.
I would highly recommend beholder because the art and music style perfectly captures the story. The struggle between the decisions is one that causes real struggle and emotional turmoil. This may not be a game you come back to over and over, but you’re going to sink your time into a few play throughs to try and make the ‘right’ decisions, whatever they may be.